Dr. Rajesh A Shenoi

Senior Scientist

Centre for Drug Discovery

email: rajeshananthashenoi@mgu.ac.in, rshenoi@gmail.com

Mob: +91 7034345031

Thrust area

our research team primarily focuses on the design and development of advanced polymeric biomaterials for biomedical applications. His thrust areas include the synthesis of novel and biodegradable biomaterials tailored for targeted drug delivery, particularly to enhance the intracellular delivery of therapeutic agents. He explores macromolecular drugs and prodrugs, as well as stimuli-responsive nanostructures, to achieve precise and efficient therapeutic outcomes. Additionally, his work in nanomedicine aims to improve the potency and bioavailability of herbal formulations, offering innovative strategies for integrating traditional medicine with modern drug delivery systems.

Research Team

Academic Positions

Scientist D (Adhoc) (2015-2016)

Biomedical Technology Wing, Sree Chitra Tirunal Institute for Medical Sciences and Technology, Thiruvananthapuram

Visiting Faculty (2014-2015)

International and Inter University Centre for Nanoscience and Nanotechnology, Mahatma Gandhi University, Kottayam.

Postdoctoral Research Fellow (2008-2014)

Centre for Blood Research and Department of Pathology & Laboratory Medicine, University of British Columbia, Vancouver BC, Canada

Scientist/Engineer ‘SC’ (2004-2008)

Vikram Sarabhai Space Centre, Indian Space Research Organization, Thiruvananthapuram

Education

Ph.D. in Chemistry (1998-2004)

National Chemical Laboratory, Pune/ University of Pune

M.Sc. in Chemistry (1995-1997)

School of Chemical Sciences, Mahatma Gandhi University, Kottayam

B.Sc. in Chemistry (1992-1995)

S.D College, Alapppuza, University of Kerala.

Awards and Fellowships

2000- Council for Scientific and Industrial Research Senior Research Fellowship

1998- Council for Scientific and Industrial Research Junior Research Fellowship

1998- Qualified Graduate Aptitude Test in Engineering (Chemistry) (GATE-97) with percentile score of 96.90 (All India Rank: 46).

Memberships

Member of International Society for Neurochemistry (2019)
Member of International Chemical Biology Society (2017, 2018, 2019 )
Annual Member of the American Chemical Society, USA (2011)
Annual Member of the Canadian Biomaterials Society (2011)
Life Member of the Society for Polymer Science, India (2003 onwards)
Life Member of the High Energy Materials Society of India (2005 onwards)
Life Member of Indian Academy of Neurosciences (2023 onwards)

Grants received

Bioengineered dendritic polyglycerol based thermoresponsive microsheets for neuronal tissue transplantation in Parkinson’s disease (Ongoing, 2025-2028), Role: Principal Investigator, Funding agency: ICMR, Govt. of India, Amount: INR 77.70 Lakhs
Revolutionizing neural regeneration: Developing a 4D bioprinting method for neural tissue engineering and transplantation (Approved in 2025), Role: Co-Investigator, Funding agency: ICMR, Government of India, Amount: Rs. 100 Lakhs
In vivo biological evaluation of nanoformulated lysophosphatidyl choline-EPA for neuro-restoration following stroke in experimental animals (ongoing 2022-2025), Role: Co-Investigator, Funding Agency: DHR, Governmenrt of India, Amount: Rs. 42 Lakhs
Profiling in vivo substrates of palmitoyl-protein thioesterase-1 as a quest for novel therapies for infantile neuronal ceriod lipofuscinosis (completed, 2021-2024), Role: Co-Investigator, Funding Agency: ICMR, Governmenrt of India, Amount: Rs. 65 Lakhs
Engineered dendritic polymer nanoparticles for targeting the mitochondria in neurodegenerative diseases (completed, 2020-2023), Role: Principal Investigator, Funding Agency: SERB, Governmenrt of India, Amount: Rs. 31.25 Lakhs

Patents

Granted

Kizhakkedathu JN, Morrissey JH, Travers RJ, Shenoi RA and Kalathottukaren MT. Antithrombotic compounds, methods and uses thereof. US Patent 10202507B2 (Date of patent: Feb 12, 2019)
Kizhakkedathu JN, Shenoi RA, Carter CJ and Brooks DE. Polymers for reversing heparin based anticoagulation. US Patents 20120308546 (December 6, 2012), 8519189 (August 27, 2013), 8637008 (January 28, 2014), 9095666 (August 4, 2015).

Filed

Brooks D, Kizhakkedathu J, Shenoi R, Weinhart M, Haag R, Groeger D. Anionic linear polyglycerol derivatives, a method for manufacturing and applications. PCT Application WO 2016116489. (Date of filing: January 20, 2016)
Khan MK, Kizhakkedathu JN, Misri R, Shenoi RA, Wong NKY and Brooks DE. Hydrophobically derivatized hyperbranched polyglycerol for intravascular drug delivery. PCT Application WO 2016000070 (Date of filing: June 26, 2015)
Kizhakkedathu JN, Morrissey JH, Travers RJ, Shenoi RA and Kalathottukaren MT. Antithrombotic compounds, methods and uses thereof. PCT Application WO 2015179958 (Date of filing: May 29, 2015)
Kizhakkedathu J, Shenoi R, Manoharan M, Kallanthottathil R and Narayanannair JK. Polyacetal or polyketal and polyether polymers. PCT Application WO 2011140644 (Date of filing: May 11, 2011).
Kizhakkedathu JN, Morrissey JH, Travers RJ, Shenoi R and Kalathottukaren MT. Antithrombotic compounds, methods and uses thereof. US Patent Application 15/313774 (2017)
Brooks D, Kizhakkedathu J, Shenoi R, Weinhart M, Lai B, Haag R, Groeger D. Anionic linear polyglycerol derivatives, a method for manufacturing and applications. US Patent Application 15/545272 (2018)

Recent publications

Cumulative IF: 156; h-index: 17; Total Citations: 1076

Keethedath N, Shenoi RA. Mitochondria-targeted nanotherapeutics: A new frontier in neurodegenerative disease treatment. Mitochondrion, , https://doi.org/10.1016/j.mito.2024.102000 (2025) (IF:3.9)
Saji CV, Mohanakumar KP, Shenoi RA. Phytomedicine nanoformulations for Parkinson’s disease. Phytomedicine Plus 5, https://doi.org/10.1016/j.phyplu.2024.100704 (2025)\
Ranjith GP, Jisha S, Hemanthakumar AS, Saji CV, Shenoi RA and Sabu KK. Impact of potential stimulants on asiaticoside and madecassoside levels and expression of triterpenoid-relatedgenes in axenic shoot cultures of Centella asiatica (L.) Urb. Phytochemistry 186, 112735 (2021) (IF:4.072)
Abbina S, Takeuchi LE, Anilkumar P, Yu K, Rogalski JC, Shenoi RA, Constantinescu I, Kizhakkedathu JN. Blood circulation of soft nanomaterials is governed by dynamic remodeling of protein opsonins at nano-biointerface. Nat Commun 11, 3048 (2020) (IF: 14.919)
Chandra G*, Shenoi RA*, Anand R, Rajamma U, and Mohanakumar KP. Reinforcing mitochondrial functions in aging brain: An insight into Parkinson’s disease therapeutics. J Chem. Neuroanat.95, 29-42 (2019) (*equal first author contribution) (IF: 1.925).
Schmitt V, Rodríguez-Rodríguez C, Hamilton JL, Shenoi RA, Schaffer P, Sossi V,Kizhakkedathu JN, Saatchi K and Häfeli UO. Quantitative SPECT imaging and biodistributionpoint to molecular weight independent tumor uptake for some long-circulating polymer nanocarriers. RSC Advances 8, 5586-5595 (2018). (IF: 3.108).

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